Association between GST Genetic Polymorphism and Dose-Related Production of Urinary Benzene Metabolite Markers, trans, trans-Muconic Acid and S-Phenylmercapturic Acid
نویسندگان
چکیده
منابع مشابه
Association between GST genetic polymorphism and dose-related production of urinary benzene metabolite markers, trans, trans-muconic acid and S-phenylmercapturic acid.
The urinary benzene metabolites, trans, trans-muconic acid (ttMA) and S-phenylmercapturic acid (SPMA), are widely used as benzene exposure biomarkers. The influence of the glutathione S-transferase (GST) genetic polymorphism on the excretion levels of urinary ttMA and/or SPMA has been investigated. The association between dose-related production of urinary benzene metabolites and benzene exposu...
متن کاملBiological monitoring of exposure to benzene: a comparison between S-phenylmercapturic acid, trans,trans-muconic acid, and phenol.
OBJECTIVES Comparison of the suitability of two minor urinary metabolites of benzene, trans,trans-muconic acid (tt-MA) and S-phenylmercapturic acid (S-PMA), as biomarkers for low levels of benzene exposure. METHODS The sensitivity of analytical methods of measuring tt-MA and S-PMA were improved and applied to 434 urine samples collected from 188 workers in 12 studies in different petrochemica...
متن کاملPersonal exposure to different levels of benzene and its relationships to the urinary metabolites S-phenylmercapturic acid and trans,trans-muconic acid.
This report is part of an extensive study to verify the validity, specificity, and sensitivity of biomarkers of benzene at low exposures and assess their relationships with personal exposure and genetic damage. The study population was selected from benzene-exposed workers in Tianjin, China, based on historical exposure data. The recruitment of 130 exposed workers from glue-making or shoe-makin...
متن کاملbenzene-induced changes in hematological parameters and urinary trans, trans-muconic acid among gasoline station workers
[no abstract available]
متن کاملOccupational exposure to benzene and changes in hematological parameters and urinary trans, trans-muconic acid.
BACKGROUND For its toxicity, benzene exposure is one of the main health concerns for high risk occupations like gasoline station workers. However, there is little knowledge about the effect of benzene metabolites on hematological parameters. OBJECTIVE To evaluate the correlation between the urinary level of trans, trans-muconic acid (t, t-MA), a benzene metabolite, and some hematological para...
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ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2008
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-08-0160